The musical revolves around the antics of Mame Dennis, a fun-loving, wealthy eccentric with a flare for life and a razor sharp wit. Her life is suddenly changed when she becomes the guardian of her late brother's only child, Patrick Dennis. Her adventures take us from the speak-easies of the roaring 20's to the depression following the great Stock Market crash. She is rescued by a wealthy Southern plantation owner, marries and is widowed suddenly, and through it all, manages to keep things under control. With some help from her dearest friend, Vera Charles, she helps keep things at 3 Beekman Place a rousing free-for-all.

Journalist Steve O'Malley wants to write a biography of a national hero who died when his car ran off a bridge. Steve receives conflicting reports and tales that make him question what the truth about the hero is.

It's 1928 in oil rich southeast Kansas. High school seniors Bud Stamper and Deanie Loomis are in love with each other. Bud, the popular football captain, and Deanie, the sensitive soul, are "good" kids who have only gone as far as kissing. Unspoken to each other, they expect to get married to each other one day. But both face pressures within the relationship, Bud who has the urges to go farther despite knowing in his heart that if they do that Deanie will end up with a reputation like his own sister, Ginny Stamper, known as the loose, immoral party girl, and Deanie who will do anything to hold onto Bud regardless of the consequences. They also face pressures from their parents who have their own expectation for their offspring. Bud's overbearing father, Ace Stamper, the local oil baron, does not believe Bud can do wrong and expects him to go to Yale after graduation, which does not fit within Bud's own expectations for himself...